SANTA CLARA, CA--(Marketwire - January 13, 2009) - Symyx Technologies, Inc. (NASDAQ: SMMX) today announced that Schering-Plough Corporation has licensed Symyx Notebook to equip Schering-Plough research scientists with a single, enterprise-wide electronic lab notebook across the company's global R&D operations.

"By providing a common, shared notebook across the enterprise, Symyx Notebook facilitates enhanced compliance, greatly improved collaboration between researchers, and support for integration and harmonization of procedures across R&D facilities," said Trevor Heritage, President, Symyx Software. "We look forward to supporting Schering Plough's efforts to speed the discovery and development of innovative pharmaceutical products that deliver better outcomes for patients."

Schering-Plough will also collaborate with Symyx to develop within the Symyx Notebook a commercial metrology module built on the Symyx Lab Operational Informatics platform. The metrology module will enable researchers to track and manage equipment usage and calibration directly within their Notebook workflows.

Symyx Notebook is a powerful, easy-to-use ELN that meets the needs of many scientific disciplines without the need for custom coding. Built on a proven, robust, scalable and secure informatics platform, Symyx Notebook consolidates experimental data from multiple domains into fully versioned, shareable and searchable documents controlled by customizable document workflows with secure document versioning, electronic signatures and audit trails. By enabling global, diversified research teams to deploy and maintain a single notebook application enterprise-wide, Symyx Notebook streamlines lab operations, enhances collaboration, lowers costs and accelerates productivity.

For more information about Symyx Notebook, visit www.symyx.com/notebook6 or contact inforequest@symyx.com.

About Symyx

Symyx Technologies, Inc. (NASDAQ: SMMX) enables companies in life sciences, chemicals and energy, and consumer and industrial products to transform scientific R&D and achieve extraordinary breakthroughs in productivity and return on investment. Symyx scientific information management enables scientists to design, execute, analyze, and report experimental results faster, easier, and less expensively. Symyx microscale, parallel experimentation enables a single scientist to rapidly explore a broad experimental space and develop comprehensive data sets in days -- not weeks or months. Symyx contract research delivers these advantages on a customer-directed project basis and enables companies to increase R&D productivity, agility, and flexibility. Information about Symyx, including reports and other information filed by Symyx with the Securities and Exchange Commission, is available at www.symyx.com.

Symyx is a registered trademark of Symyx Technologies, Inc. All rights reserved. All other trademarks mentioned in this document are the property of their respective owners.